This section presents a series of questions over material you have studied in the aminoglycoside tutorial.

Question #1:
Which of the pathogens listed below are aminoglycosides rarely used to treat?

A. Escherichia coli
B. Proteus mirabilis
C. Enterobacter aerogenes
D. Neisseria meningitidis √

Question #2:
Aminoglycosides are primarily eliminated by the kidney. Which of the following describes the mechanism of action?

A. Tubular secretion (TS)
B. Glomerular Filtration (GFR) √
C. Both by TS and GFR
D. Metabolized by the P450 system

Question #3:
Aminoglycosides do not penetrate well into which of the following fluids?

A. Peritoneal fluid
B. Cerebral Spinal Fluid √
C. Urine and bile
D. Synovial fluid

Question #4:
True or false? Tobramycin is more active than gentamicin against Pseudomonas aeruginosa?

A. True √
B. False

Question #5:
The antimicrobial activity is markedly reduced in which of the following environments?

A. Blood
B. ABSCESS (anaerobic environment; acidic pH) √
C. Alkaline urine
D. Peritoneal fluid

Question #6:
A dialysis patient being treated with an aminoglycoside and piperacillin may experience in vivo inactivated aminoglycoside.

A. True √
B. False

Question #7:
Which of the following characteristics is not true of aminoglycosides?

A. Are not adequately absorbed PO
B. Penetrate into synovial fluids with ease
C. Penetrate into CSF √
D. Are eliminated by glomerular filtration

Question #8:
True or False? Bacteria that acquire resistance to gentamicin will likely be resistant to tobramycin?

A. True √
B. False

Question #9:
True or False? The antimicrobial activity of the aminoglycosides is enhanced by an acidic environment?

A. True
B. False √

Question #10:
Which pathogen listed below would not typically be treated with an aminoglycoside?

A. Serratia marcescens
B. Klebsiella pneumoniae
C. Escherichia coli
D. Haemophilus influenzae √

Question #11:
True or False? Aminoglycosides are effective alone against Streptococcus pneumoniae and Streptococcus.

A. True
B. False (gram positive organisms) √

Question #12:
True or False? In healthy volunteers, 85 to 95% of the aminoglycoside dose is eliminated unchanged.

A. True √
B. False

Question #13:
True or False? Aminoglycosides are effective treatment for gram negative infections caused by Escherichia , Klebsiella, Enterobacter, and Serratia species but not those caused by Pseudomonas aeruginosa.

A. True
B. False √

Question #14:
Which antibiotic(s) listed below would be optimal for an enterococcal infection?

A. Ampicillin alone
B. A combination of ampicillin and gentamicin √
C. A combination of ampicillin and vancomycin
D. Gentamicin alone

Question #15:
True or False? An aminoglycoside could be used for a urinary tract infection caused by Enterobacter aerogenes?

A. True √
B. False

Question #16:
True or False? The antimicrobial activity of aminoglycosides is enhanced in an anaerobic environment.

A. True
B. False √