| Quiz Answers This section presents a series of questions over material you have studied in the aminoglycoside tutorial. Question #1:
Which of the pathogens listed below are aminoglycosides rarely used to treat? A. Escherichia coli
B. Proteus mirabilis
C. Enterobacter aerogenes
D. Neisseria meningitidis Question #2:
Aminoglycosides are primarily eliminated by the kidney. Which of the following describes the mechanism of action? A. Tubular secretion (TS)
B. Glomerular Filtration (GFR)
C. Both by TS and GFR
D. Metabolized by the P450 system Question #3:
Aminoglycosides do not penetrate well into which of the following fluids? A. Peritoneal fluid
B. Cerebral spinal fluid
C. Urine and bile
D. Synovial fluid Question #4:
True or false? Tobramycin is more active than gentamicin against Pseudomonas aeruginosa? A. True
B. False Question #5:
The antimicrobial activity is markedly reduced in which of the following environments? A. Blood
B. Abscess (anaerobic environment; acidic pH)
C. Alkaline urine
D. Peritoneal fluid Question #6:
A dialysis patient being treated with an aminoglycoside and piperacillin may experience in vivo inactivated aminoglycoside. A. True
B. False Question #7:
Which of the following characteristics is not true of aminoglycosides? A. Are not adequately absorbed PO
B. Penetrate into synovial fluids with ease
C. Penetrate into CSF
D. Are eliminated by glomerular filtration Question #8:
True or False? Bacteria that acquire resistance to gentamicin will likely be resistant to tobramycin? A. True
B. False Question #9:
True or False? The antimicrobial activity of the aminoglycosides is enhanced by an acidic environment? A. True
B. False Question #10:
Which pathogen listed below would not typically be treated with an aminoglycoside? A. Serratia marcescens
B. Klebsiella pneumoniae
C. Escherichia coli
D. Haemophilus influenzae Question #11:
True or False? Aminoglycosides are effective alone against Streptococcus pneumoniae and Streptococcus. A. True
B. False Question #12:
True or False? In healthy volunteers, 85 to 95% of the aminoglycoside dose is eliminated unchanged. A. True
B. False Question #13:
True or False? Aminoglycosides are effective treatment for gram negative infections caused by Escherichia , Klebsiella, Enterobacter, and Serratia species but not those caused by Pseudomonas aeruginosa. A. True
B. False Question #14:
Which antibiotic(s) listed below would be optimal for an enterococcal infection? A. Ampicillin alone
B. A combination of ampicillin and gentamicin
C. A combination of ampicillin and vancomycin
D. Gentamicin alone Question #15:
True or False? An aminoglycoside could be used for a urinary tract infection caused by Enterobacter aerogenes? A. True
B. False Question #16:
True or False? The antimicrobial activity of aminoglycosides is enhanced in an anaerobic environment. A. True
B. False Contratulations! You have completed this section. Have a nice day! | 
