| Vancomycin Pharmacology Answers QUESTION #1
True or false? Anaphylactic reactions to vancomycin are common and an alternative drug should be used when they occur?
A. True
B. False QUESTION #2
Vancomycin is a bacteriostatic antibiotic for enterococci?
A. True
B. False QUESTION #3
True or false? Vancomycin need not be used with an aminoglycoside to treat enterococcus endocarditis?
A. True
B. False QUESTION #4
Vancomycin exerts its primary antimicrobial effect by interfering with or inhibiting:
A. Protein synthesis
B. Folic acid metabolism
C. Cell wall formation
D. Carbohydrate metabolis QUESTION #5
Which of the following categories best describes vancomycin as an antibiotic?
A. Sulfonamide
B. Aminoglycoside
C. Macrolide
D. Glycopeptide QUESTION #6
Which of the following micro-organisms is not included in vancomycin's antimicrobial spectrum?
A. Staphylococcus species
B. Streptococcus species
C. E. coli
D. Clostridium difficile QUESTION #7
The red-neck syndrome is:
A. Histamine related
B. Infusion related
C. Both histamine and infusion related QUESTION #8
Which of the following adverse reactions is most likely to occur in the administration of vancomycin?
A. Phlebitis
B. Neutropenia
C. Fever
D. Rash QUESTION #9
Which of the following is not characteristic of the so-called red-neck syndrome?
A. Often occurs after a 1 hour infusion
B. Produces hypotension
C. Produces tachycardia
D. Resolves within 10-20 minutes after discontinuing vancomycin QUESTION #10
Vancomycin may be administered by all of the following routes except:
A. Oral administration
B. Intramuscular administration
C. Intravenous administration
D. It can be given by all of the above routes QUESTION #11
For tolerant strains of Staphylococcus, which antibiotics would you add to the regimen?
A. Rifampin
B. Aminoglycosides
C. Macrolides
D. A and B QUESTION #12
Bacterial tolerance is defined as a situation when the minimum inhibiting concentration can be divided into the minimum bactericidal concentration with the resulting division being equal to or greater than:
A. 16
B. 32
C. 64
D. 128 QUESTION #13
Which of the following adverse reactions has not been associated with vancomycin?
A. Hepatotoxicity
B. Infusion related hypotension
C. Nephrotoxicity QUESTION #14
Ototoxicity has been reported to be associated with:
A. Peak concentrations > 80-100 mg/liter
B. Trough concentrations > 20 mg/liter
C. Peak concentrations > 20 mg/liter
D. None of the above QUESTION #15
Nephrotoxicity has been associated with vancomycin serum concentrations of:
A. Peak concentrations > 80-100 mg/liter
B. Trough concentrations > 20 mg/liter
C. Peak concentrations > 50 mg/liter
D. None of the above QUESTION #16
True or false? Systemic infections can be treated with either oral or IV vancomycin.
A. True
B. False | 
